Recombinant Human Sirtuin 6, GST-tagged
Cat.No. : | SIRT6-4883H |
Product Overview : | Full-length recombinant human SIRT6 was expressed in E. coli cells using an N-terminal GST tag. |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Description : | SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD (+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. |
Applications : | Western Blot |
Molecular Weight : | 66 kDa |
Expression System : | E. coli |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1mM PMSF, 25 % glycerol. |
Purity : | > 85 % |
Concentration : | 0.2 ug/ul |
Sequences : | Full-length |
Storage : | Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Signaling events mediated by HDAC Class I |
Gene Name | SIRT6 sirtuin 6 [ Homo sapiens ] |
Official Symbol | SIRT6 |
Synonyms | SIRT6; sirtuin 6; SIR2L6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6; sir2-related protein type 6; EC 2.4.2.31; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6 |
Gene ID | 51548 |
mRNA Refseq | NM_016539 |
Protein Refseq | NP_057623 |
MIM | 606211 |
UniProt ID | Q8N6T7 |
Chromosome Location | 19p13.3 |
Function | NAD binding; NAD (P)+-protein-arginine ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; hydrolase activity; metal ion binding; protein binding; transferase activity, transferring glycosyl groups; zinc ion binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific) |
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◆ Cell & Tissue Lysates | ||
SIRT6-1829HCL | Recombinant Human SIRT6 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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