Active Recombinant Human SIRT6 Protein, GST-tagged

Cat.No. : SIRT6-28517H
Product Overview : Human Sirtuin 6 (GenBank Accession No. NM_016539), full length with N-terminal GST-tag was expressed in an E. coli expression system.
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Species : Human
Source : E.coli
Tag : GST
Description : This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms.
Form : Aqueous buffer solution
Bio-activity : 1.5 pmol/min/µg
Assay Conditions: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 µM BPS SIRT6 substrate 2, 500 µM NAD+ and Sirtuin 6 (18 – 2000 ng). Incubation condition: 60 min at 37ºC followed by developing for 15 min at room temperature.
Molecular Mass : 65 kDa
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : At least 6 months at –80 centigrade. Avoid freeze/thaw cycles.
Storage Buffer : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol
Warning : Avoid freeze/thaw cycles.
Full Length : Full L.
Gene Name SIRT6 sirtuin 6 [ Homo sapiens (human) ]
Official Symbol SIRT6
Synonyms SIRT6; sirtuin 6; SIR2L6; NAD-dependent protein deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6; EC 2.4.2.31
Gene ID 51548
mRNA Refseq NM_016539
Protein Refseq NP_057623
MIM 606211
UniProt ID Q8N6T7

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