Active Recombinant Human SIRT6 Protein, GST-tagged
Cat.No. : | SIRT6-28517H |
Product Overview : | Human Sirtuin 6 (GenBank Accession No. NM_016539), full length with N-terminal GST-tag was expressed in an E. coli expression system. |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Description : | This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Form : | Aqueous buffer solution |
Bio-activity : | 1.5 pmol/min/µg Assay Conditions: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 µM BPS SIRT6 substrate 2, 500 µM NAD+ and Sirtuin 6 (18 – 2000 ng). Incubation condition: 60 min at 37ºC followed by developing for 15 min at room temperature. |
Molecular Mass : | 65 kDa |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. |
Storage Buffer : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol |
Warning : | Avoid freeze/thaw cycles. |
Full Length : | Full L. |
Gene Name | SIRT6 sirtuin 6 [ Homo sapiens (human) ] |
Official Symbol | SIRT6 |
Synonyms | SIRT6; sirtuin 6; SIR2L6; NAD-dependent protein deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6; EC 2.4.2.31 |
Gene ID | 51548 |
mRNA Refseq | NM_016539 |
Protein Refseq | NP_057623 |
MIM | 606211 |
UniProt ID | Q8N6T7 |
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Not For Human Consumption!
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