Recombinant Human SIRT2, His-tagged
Cat.No. : | SIRT2-30567TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 50-356 of Human SIRT2, with C-terminal His tag, 35.5 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 50-356 a.a. |
Description : | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. |
Conjugation : | HIS |
Tissue specificity : | Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulatio |
Biological activity : | Specific Activity: 1.4 U/μg. One U =1 pmol/min. |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain. |
Gene Name | SIRT2 sirtuin 2 [ Homo sapiens ] |
Official Symbol | SIRT2 |
Synonyms | SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2; |
Gene ID | 22933 |
mRNA Refseq | NM_001193286 |
Protein Refseq | NP_001180215 |
MIM | 604480 |
Uniprot ID | Q8IXJ6 |
Chromosome Location | 19q13 |
Pathway | Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem; |
Function | NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; |
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Not For Human Consumption!
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