Recombinant Full Length Human SIRT2 Protein (Met1-Gln389), N-GST tagged

• Cat.No.: SIRT2-5759H
• Product Overview: Recombinant human SIRT2 (Met1-Gln389) fused with the N-GST tag was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 70.02 kDa
• Protein length: Met1-Gln389
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: SIRT2 sirtuin 2 [ Homo sapiens (human) ]
• Official Symbol: SIRT2
• Synonyms: SIRT2; sirtuin 2; SIR2L, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae), sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; SIR2-like protein 2; sir2-related protein type 2; silent information regulator 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491
• Gene ID: 22933
• mRNA Refseq: NM_030593
• Protein Refseq: NP_085096
• MIM: 604480
• UniProt ID: Q8IXJ6

Reviews

04/15/2021

Efficient and knowledgeable customer service—made our purchase straightforward.

11/02/2020

This recombined protein is our go-to for dependable and accurate results.

08/30/2018

Punctual delivery is crucial, and this product arrived right on time.

Q&As

How does SIRT2 participate in the regulation of cellular stress responses?

SIRT2 is involved in stress response pathways, deacetylating and modulating the activity of stress-responsive proteins, contributing to cellular adaptation to various stress conditions.

How does SIRT2 contribute to the regulation of cellular metabolism?

SIRT2 influences cellular metabolism by deacetylating enzymes involved in glycolysis, fatty acid metabolism, and mitochondrial function, impacting overall energy homeostasis.

Explain the molecular mechanisms underlying SIRT2-mediated deacetylation of target proteins.

SIRT2 uses NAD+ as a cofactor to remove acetyl groups from lysine residues, a process that links cellular metabolic state to protein acetylation and deacetylation.

Discuss the role of SIRT2 in the regulation of cell cycle progression.

SIRT2 influences cell cycle progression by deacetylating key regulators, such as cyclin-dependent kinases (CDKs) and checkpoint proteins, impacting cell cycle checkpoints and progression.

Discuss the role of SIRT2 in neurodegenerative diseases and its potential as a therapeutic target.

SIRT2 has been implicated in neurodegenerative diseases, and modulating its activity is explored as a potential therapeutic strategy for conditions such as Parkinson's disease.