Recombinant Human SIGIRR

• Cat.No.: SIGIRR-1681H

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Non
• Description: Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family. It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling. It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.
• Molecular Weight: The predicted molecular weight of Recombinant Human SIGIRR is Mr 39 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55-60 kDa.
• State Of Matter: Lyophilized.
• Purity: >90% by SDS Page and analyzed by silver stain.
• Endotoxin: <0.1 ng per 1 µg as determined by the LAL method.
• Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Gene Information

• Gene Name: SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [ Homo sapiens ]
• Synonyms: SIGIRR; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; TIR8; MGC110992; single Ig IL-1R-related molecule; single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; single immunoglobulin and toll-interleukin 1 receptor domain; Single Ig IL-1-related receptor
• Gene ID: 59307
• mRNA Refseq: NM_001135053
• Protein Refseq: NP_001128525
• MIM: 605478
• UniProt ID: Q6IA17
• Chromosome Location: 11p15.5
• Function: protein binding; transmembrane receptor activity