Recombinant Human SHC1, His-tagged

• Cat.No.: SHC1-3579H
• Product Overview: Recombinant human SHC1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques (1-474aa).

Specification

• Cat. No.: SHC1-3579H
• Description: SHC1 (SHC-transforming protein 1) belongs to the SH2 domain family. SHC1 has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells. It is a signaling adapter that couples activated growth factor receptors to signaling pathway. SHC1 expressed in neural stem cells but absent in mature neurons.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 2mM DTT,20% glycerol, 200mM NaCl, 0.1mM PMSF
• Molecular Weight: 53.8kDa (494aa)
• Purity: > 90% by SDS - PAGE
• Concentration: 1mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM PITLTVSTSS LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL ECPEGLAQDV ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY NDFPGKEPPL GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM PPPPPCPAGR ELFDDPSYVN VQNLDKARQA VGGAGPPNPA INGSAPRDLF DMKPFEDALR VPPPPQSVSM AEQLRGEPWF HGKLSRREAE ALLQLNGDFL VRESTTTPGQ YVLTGLQSGQ PKHLLLVDPE GVVRTKDHRF ESVSHLISYH MDNHLPIISA GSELCLQQPV ERKL
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SHC1 SHC (Src homology 2 domain containing) transforming protein 1 [ Homo sapiens ]
• Official Symbol: SHC1
• Synonyms: SHC1; SHC; SHCA; FLJ26504; SHC (Src homology 2 domain containing) transforming protein 1; SHC-transforming protein 1; OTTHUMP00000035407; OTTHUMP00000035408; OTTHUMP00000035409; OTTHUMP00000035471; OTTHUMP00000035472; SH2 domain protein C1; SHC-transforming protein 3; SHC-transforming protein A; src homology 2 domain-containing-transforming protein C1; SHC (Src homology 2 domain-containing) transforming protein 1; Src homology 2 domain-containing-transforming protein C1
• Gene ID: 6464
• mRNA Refseq: NM_001130040
• Protein Refseq: NP_001123512
• MIM: 600560
• UniProt ID: P29353
• Chromosome Location: 1q21
• Function: epidermal growth factor receptor binding; insulin receptor binding; insulin-like growth factor receptor binding; phospholipid binding; protein binding; transmembrane receptor protein tyrosine kinase adaptor activity