Recombinant Human SH2B3 Mutant (R262W) Protein, Myc/DDK-tagged

• Cat.No.: SH2B3-051H
• Product Overview: Purified mutant recombinant protein of Human SH2B adaptor protein 3 (SH2B3), mutation at (R262W) with a Myc/DDK tag was expressed in HEK293

Specification

• Description: This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Molecular Mass: 63 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: > 50 μg/mL as determined by microplate Bradford method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: SH2B3 SH2B adaptor protein 3 [ Homo sapiens (human) ]
• Official Symbol: SH2B3
• Synonyms: SH2B3; SH2B adaptor protein 3; LNK; IDDM20; SH2B adapter protein 3; lymphocyte-specific adapter protein Lnk; signal transduction protein Lnk; truncated SH2B3
• Gene ID: 10019
• mRNA Refseq: NM_005475
• Protein Refseq: NP_005466
• MIM: 605093
• UniProt ID: Q9UQQ2