Recombinant Human SETD7 Protein, His-tagged

• Cat.No.: SETD7-22H
• Product Overview: Recombinant human SETD7(1-366) protein with a N-terminal His-tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-366
• Description: Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10. Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation. SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.
• Molecular Mass: 43.3 kDa
• Purity: ≥95% estimated by SDS-PAGE
• Stability: ≥ 6 months
• Storage: Store it at -80 centigrade
• Storage Buffer: 50 mM HEPES, pH 7.2, 100 mM sodium chloride, and 20% glycerol

Gene Information

• Gene Name: SETD7 SET domain containing 7, histone lysine methyltransferase [ Homo sapiens (human) ]
• Official Symbol: SETD7
• Synonyms: SETD7; SET domain containing 7, histone lysine methyltransferase; KMT7; SET7; SET9; SET7/9; histone-lysine N-methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; lysine N-methyltransferase 7
• Gene ID: 80854
• mRNA Refseq: NM_001306199
• Protein Refseq: NP_001293128
• MIM: 606594
• UniProt ID: Q8WTS6