Recombinant Human SERPINB4 Protein, His-tagged

• Cat.No.: SERPINB4-211H
• Product Overview: Biotinylated Recombinant Human Serpin B3 is produced by E.coli. The target gene encoding M1- P390 is expressed with a 6His tag at the C terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Description: Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpins are known to inhibit serine proteases and some can inhibit caspases and papain-like cysteine proteases. Serpin B3 is also a member of the subgroup ovalbumin-related serpins which takes part in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. Serpin B3 is also a tumor marker for squamous cell carcinomas in diverse areas including the cervix, head, neck and lung. Different from typical serpins, serpin B3 inhibits papain-like lysosomal cysteine proteases Cathepsin K, L, and S, while lacking inhibitory activity against serine proteases.
• Form: Lyophilized frum a 0.2 um filtered solution of 2umM Na2HPO4, 2umM NaH2PO4, pH7.4.
• Molecular Mass: Predicted Molecular Weight: 48.1kDa
  Apparent Molecular Weight: SCCA-1 protein appeared at 47kDa in a reducing SDS-PAGE gel.
• AA Sequence: M1-P390
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Purity: >95%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
• Reconstitution: It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Quality Statement: Purity: greater than 95% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped on dry ice pack.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: SERPINB4 serpin family B member 4 [ Homo sapiens (human) ]
• Official Symbol: SERPINB4
• Synonyms: Serpin B3; Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1; Squamous cell carcinoma antigen 1; T4-A; PI11; SCCA1; SCCA2; LEUPIN; SCCA-2
• Gene ID: 6318
• mRNA Refseq: NM_002974.4
• Protein Refseq: NP_002965.1
• MIM: 600518
• UniProt ID: P29508