Recombinant Human SERPINA5, His-tagged

• Cat.No.: SERPINA5-486H
• Product Overview: Recombinant human Serpin A5 protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 45.9 kDa (408aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Serpin A5, also known as PCI (Protein C Inhibitor) or PAI3 (plasminogen activator inhibitor 3), is a member of the serpin serine proteinase inhibitor family. This protein inhibits plasminogen activators as well as activated protein C. Serpin A5 is secreted in plasma, but is also expressed in liver. Serpin A5 is involved in cell inflammation, proliferation, apoptosis, tumour cell migration, invasion, and metastasis.
• Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MHRHHPREMK KRVEDLHVGA TVAPSSRRDF TFDLYRALAS AAPSQNIFFS PVSISMSLAM LSLGAGSSTK MQILEGLGLN LQKSSEKELH RGFQQLLQEL NQPRDGFQLS LGNALFTDLV VDLQDTFVSA MKTLYLADTF PTNFRDSAGA MKQINDYVAK QTKGKIVDLL KNLDSNAVVI MVNYIFFKAK WETSFNHKGT QEQDFYVTSE TVVRVPMMSR EDQYHYLLDR NLSCRVVGVP YQGNATALFI LPSEGKMQQV ENGLSEKTLR KWLKMFKKRQ LELYLPKFSI EGSYQLEKVL PSLGISNVFT SHADLSGISN HSNIQVSEMV HKAVVEVDES GTRAAAATGT IFTFRSARLN SQRLVFNRPF LMFIVDNNIL FLGKVNRP
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 [ Homo sapiens ]
• Synonyms: SERPINA5; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; PCI; PAI3; PROCI; PLANH3; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5; Plasma serine protease inhibitor; Serpin A5; PAI-3; Acrosomal serine protease inhibitor; Protein C inhibitor; plasminogen activator inhibitor III; plasminogen activator inhibitor-3
• Gene ID: 5104
• mRNA Refseq: NM_000624
• Protein Refseq: NP_000615
• MIM: 601841
• UniProt ID: P05154
• Chromosome Location: 14q32.1
• Pathway: Complement and coagulation cascades
• Function: acrosin binding; heparin binding; peptidase inhibitor activity; protease binding; protein binding; serine-type endopeptidase inhibitor activity