Recombinant Human SERPINA1

• Cat.No.: SERPINA1-518H
• Product Overview: Recombinant Antitrypsin protein was expressed inE.coliand purified by using conventional chromatography techniques. MW = 44.4 kDa (395 aa).

Specification

• Cat. No.: SERPINA1-518H
• Description: Alpha 1 proteinase inhibitor (Antitrypsin) has a characteristicsecondary structureof beta sheets and alpha helices. That is a serum glycoprotein synthesized in the liver. It acts as an elastase inhibitor, primarily inhibiting neutrophil elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. Also Increase in Antitrypsin occurs as an acute phase response to tissue necrosis and inflammation. Serum level of Antitrypsin is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
• Source: E.coli.
• Amino Acid Sequence: MEDPQGDAAQ KTDTSHHDQD HPTFNKITPN LAEFAFSLYR QLAHQSNSTN IFFSPVSIAT AFAMLSLGTK ADTHDEILEG LNFNLTEIPE AQIHEGFQEL LRTLNQPDSQ LQLTTGNGLF LSEGLKLVDK FLEDVKKLYH SEAFTVNFGD TEEAKKQIND YVEKGTQGKI VDLVKELDRD TVFALVNYIF FKGKWERPFE VKDTEEEDFH VDQVTTVKVP MMKRLGMFNI QHCKKLSSWV LLMKYLGNAT AIFFLPDEGK LQHLENELTH DIITKFLENE DRRSASLHLP KLSITGTYDL KSVLGQLGIT KVFSNGADLS GVTEEAPLKL SKAVHKAVLT IDEKGTEAAG AMFLEAIPMS IPPEVKFNKP FVFLMIDQNT KSPLFMGKVV NPTQK.
• Form: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 1 mM DTT, 2 mM EDTA, 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Tag: Non

Gene Information

• Gene Name: SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 [ Homo sapiens ]
• Synonyms: SERPINA1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; PI; A1A; AAT; PI1; A1AT; MGC9222; PRO2275; MGC23330; serine proteinase inhibitor, clade A, member 1; OTTHUMP00000197150; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin serine (or cysteine) proteinase inhibitor, clade A, member 1
• Gene ID: 5265
• mRNA Refseq: NM_000295
• Protein Refseq: NP_000286
• MIM: 107400
• UniProt ID: P01009
• Chromosome Location: 14q32.1
• Pathway: Complement and coagulation cascades; Hemostasis
• Function: peptidase activity; peptidase inhibitor activity; protease binding; protein binding; serine-type endopeptidase inhibitor activity