SERPINA1
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Official Full Name
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -
Overview
The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. -
Synonyms
SERPINA1;serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1;PI;A1A;AAT;PI1;A1AT;MGC9222;PRO2275;MGC23330;serine proteinase inhibitor, clade A, member 1;OTTHUMP00000197150;protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin serine (or cysteine) proteinase inhibitor, clade A, member 1
Recombinant Proteins
- Human
- Rat
- Horse
- Rhesus macaque
- Zebrafish
- Chicken
- Mouse
- Dog
- HEK293
- Rice Grain
- E.coli
- Oryza Sativa
- Mammalian Cell
- E.Coli or Yeast
- Human Cell
- E. coli
- Yeast
- HEK293T
- Mammalian cells
- Human Plasma
- human plasma
- His
- Non
- N-GST
- Myc&DDK
- His&Fc&Avi
- Flag
- His&SUMO
Involved Pathway
SERPINA1 involved in several pathways and played different roles in them. We selected most pathways SERPINA1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C2,C1S,Serpina1c,C9,FGB,C8G,BDKRB1,CPB2,F5,F9 |
Protein Function
SERPINA1 has several biochemical functions, for example, glycoprotein binding,identical protein binding,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINA1 itself. We selected most functions SERPINA1 had, and list some proteins which have the same functions with SERPINA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glycoprotein binding | IGF2R,OS9,CD4,F7,AZGP1,TGFB1,EDEM2,RASA1,FBXO17,RAB14 |
| protein binding | SORL1,CETN3,FAM86C,USH2A,KLHDC5,CCK,PDZD11,GABARAPL2,PPP6R2,CYTH1 |
| protease binding | ALPI,Cstb,SERPINF2,SERPINB3,XBP1,CD28,SERPINB6,TIMP4,F3,LRP1 |
| serine-type endopeptidase inhibitor activity | PEBP1,WFDC13,SPINK7,APPB,COL28A1,SERPINB3,WFDC2,KAL1,SERPINA1D,SERPINB6B |
| identical protein binding | NCAM1,DNM1L,NUFIP1,TTC32,TPCN1,ESYT2,SCUBE1,CPT1A,VWF,CD28 |
Interacting Protein
SERPINA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINA1.
try1_bovin;CELA1;SSR1;ELANE;tryp_sacer;CANX;espB
Resources
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References
- Watts, RA; MacGregor, AJ; et al. HLA allele variation as a potential explanation for the geographical distribution of granulomatosis with polyangiitis. RHEUMATOLOGY 54:359-362(2015).
- Perez-Rubio, G; Jimenez-Valverde, LO; et al. Prevalence of alpha-1 antitrypsin high-risk variants in Mexican mestizo population and their association with lung function values. ARCHIVOS DE BRONCONEUMOLOGIA 51:80-85(2015).
