Recombinant Human Serine/Threonine Kinase 39, His-tagged

• Cat.No.: STK39-1109H
• Product Overview: Recombinant full-length human STK39 (STLK3) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Cat. No.: STK39-1109H
• Description: STK39 (also known as serine threonine kinase 39) is involved in the cellular stress response pathway. STK39 is activated in response to hypotonic stress leading to phosphorylation of several cation-chloride-coupled co-transporters. STK39 activates the p38 MAP kinase pathway and its interaction with p38 decreases during cellular stress. STK39 acts as an intermediate in the response to cellular stress. STK39 is also an independent risk factor for hypertension in men and its intragenic SNPs can interact and function in the control of blood pressure.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 63 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
• Specific Activity: 22 nmol/min/mg
• Purity: > 95 %
• Concentration: 0.1 ug/ul
• Sequences: Full-length
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: T Cell Receptor Signaling Pathway; TCR signaling in naive CD4+ T cells

Gene Information

• Gene Name: STK39 serine threonine kinase 39 [ Homo sapiens ]
• Official Symbol: STK39
• Synonyms: STK39; serine/threonine kinase 39; DCHT; PASK; SPAK; DKFZp686K05124; STE20/SPS1 homolog (yeast); STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; EC=2.7.11.1; Serine/threonine-protein kinase 39; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); small intestine SPAK-like kinase; Ste20-like protein kinase; STE20/SPS1 homolog; EC 2.7.11; EC 2.7.11.1; OTTHUMP00000165175
• Gene ID: 27347
• mRNA Refseq: NM_013233
• Protein Refseq: NP_037365
• MIM: 607648
• UniProt ID: Q9UEW8
• Chromosome Location: 2q24.3
• Function: ATP binding; nucleotide binding; protein kinase binding; receptor sinaling protein serine/threonine kinase activity