Recombinant Human Septin 2, His-tagged

• Cat.No.: SEPT2-4583H
• Product Overview: SEPT2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 381 amino acids (1-361a.a.) and having a molecular mass of 43.6kDa. SEPT2 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Specification

• Species: Human
• Source: Human
• Tag: His
• ProteinLength: 1-361 a.a.
• Description: SEPT2 is a GTPase which is mandatory for cytokinesis and related to exocytosis. Septin-2 protein is able to hetero-oligomerize with Septin6, 7 and in addition takes part in the organization of new growth in organisms. SEPT2 is associated with a Tau-based paired helical filament core and contributes to the creation of neurofibrillary tangle as integral constituents of paired helical filaments.
• Form: SEPT2 solution (0.25mg/1ml) containing 20mM Tris-HCl buffer (pH8.0),0.1M NaCl,1mM DTT and 10% glycerol.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Physical Appearance: Sterile filtered colorless solution.
• Amino acid sequence: MGSSHHHHHH SSGLVPRGSH MSKQQPTQFI NPETPGYVGF ANLPNQVHRK SVKKGFEFTL MVVGESGLGK STLINSLFLT DLYPERVISG AAEKIERTVQ IEASTVEIEE RGVKLRLTVV DTPGYGDAIN CRDCFKTIIS YIDEQFERYL HDESGLNRRH IIDNRVHCCF YFISPFGHGL KPLDVAFMKA IHNKVNIVPV IAKADTLTLK ERERLKKRIL DEIEEHNIKI YHLPDAESDE DEDFKEQTRL LKASIPFSVV GSNQLIEAKG KKVRGRLYPW GVVEVENPEH NDFLKLRTML ITHMQDLQEV TQDLHYENFR SERLKRGGRK VENEDMNKDQ ILLEKEAELR RMQEMIARMQ AQMQMQMQGG DGDGGALGHH V
• Storage: Septin2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

Gene Information

• Gene Name: SEPT2 septin 2 [ Homo sapiens ]
• Official Symbol: SEPT2
• Synonyms: SEPT2; septin 2; DIFF6; NEDD5; Pnutl3; hNedd5; KIAA0158; septin-2; NEDD-5; OTTHUMP00000200241; OTTHUMP00000200242; OTTHUMP00000200248; OTTHUMP00000200249; OTTHUMP00000200250; OTTHUMP00000200251; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed developmentally down-regulated protein 5
• Gene ID: 4735
• mRNA Refseq: NM_001008491
• Protein Refseq: NP_001008491
• MIM: 601506
• UniProt ID: Q15019
• Chromosome Location: 2q37
• Pathway: CDC42 signaling events
• Function: GTP binding; enzyme regulator activity; nucleotide binding; protein binding; protein complex scaffold