Recombinant Human Scavenger Receptor Class B, Member 1, Fc-His

• Cat.No.: SCARB1-852H
• Product Overview: A DNA sequenceencoding the mature form of human SCARB1 extracellular domain (Pro 33 - Tyr 443)was fused with a polyhistidine tag at the C-terminus.

Specification

• Species: Human
• Source: Human
• Tag: Fc&His
• Protein Length: 33-443 a.a.
• Description: SCARB1 is a member of the scavenger receptorfamily. SCARB1 is expressed primarily in liver and non-placentalsteroidogenic tissues. It binds high density lipoproteins (LDL) and mediatesselective cholesterol uptake by a mechanism distinct from the LDL pathway.High density lipoproteins (HDLs) play a critical role in cholesterolmetabolism and their plasma concentrations are inversely correlated with riskfor atherosclerosis. SCARB1 is a key component in the reverse cholesteroltransport pathway and plays an important role in lipid metabolism.
• Form: Lyophilized from sterile PBS, pH 7.4.Normally 5 % - 8 % trehalose and mannitol are added as protectants beforelyophilization. Specific concentrations are included in the hardcopy of COA.
• Purity: > 95 % as determined by SDS-PAGE
• Endotoxin: ﹤1.0 EU per μgprotein as determined by the LAL method
• Stability: Samplesare stable for up to twelve months from date of receipt at -70°C.
• Predicted N terminal: Pro 33
• Molecular Mass: The recombinanthuman SCARB1 consists of 422 amino acids and has a predicted molecular massof 48 kDa. In SDS-PAGE under reducing conditions, the apparent molecular massof rhSCARB1 is approximately 75-85 kDa due to glycosylation.
• Reconstitution: A hardcopy of COAwith reconstitution instruction is sent along with the products.
• Storage: Store it understerile conditions at -70°C upon receiving. Recommend to aliquot the proteininto smaller quantities for optimal storage. Avoid repeated freeze-thawcycles.

Gene Information

• Gene Name: SCARB1 scavenger receptor class B, member 1[ Homo sapiens ]
• Official Symbol: SCARB1
• Synonyms: SCARB1; scavengerreceptor class B, member 1; CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6; CD36 antigen (collagen type I receptor, thrombospondinreceptor)-like 1; CD36 and LIMPII analogous 1; MGC138242; OTTHUMP00000239001;OTTHUMP00000239002; OTTHUMP00000239003; OTTHUMP00000239004;OTTHUMP00000239005; OTTHUMP00000239006; scavenger receptor class Bmember 1; scavenger receptor class B type III; CD36antigen; CD36 antigen-like 1; collagen type I receptor, thrombospondinreceptor-like 1
• Gene ID: 949
• mRNA Refseq: NM_001082959
• Protein Refseq: NP_001076428
• MIM: 601040
• UniProt ID: Q8WTV0
• Chromosome Location: 12q24.31
• Pathway: Bile secretion; Fatdigestion and absorption; Folate Metabolism; HDL-mediated lipid transport;Hepatitis C; Lipid digestion, mobilization, and transport; Lipoproteinmetabolism; metabolism; Phagosome; Selenium Pathway; Statin Pathway; VitaminA and carotenoid metabolism; Vitamin digestion and absorption
• Function: 1-phosphatidylinositolbinding; apolipoprotein A-I binding; apolipoprotein binding; high-densitylipoprotein particle binding; high-density lipoprotein particle receptoractivity; lipopolysaccharide binding; lipopolysaccharide receptor activity;low-density lipoprotein particle binding; phosphatidylserinebinding; protein homodimerization activity; receptor activity;transporter activity