Recombinant Human RRBP1 protein, His & T7-tagged

• Cat.No.: RRBP1-1667H
• Product Overview: Recombinant Human RRBP1 aa. (Arg822~Val977 (Accession # Q9P2E9)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Arg822~Val977
• Description: This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12.
• Form: Freeze-dried powder
• Molecular Mass: 30kDa as determined by SDS-PAGE reducing conditions.
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.
• Isoelectric Point: 4.7

Gene Information

• Gene Name: RRBP1 ribosome binding protein 1 [ Homo sapiens (human) ]
• Official Symbol: RRBP1
• Synonyms: RRBP1; ribosome binding protein 1; RRp; hES; ES130; ES/130; ribosome-binding protein 1; 180 kDa ribosome receptor homolog; ES/130-related protein; ribosome binding protein 1 homolog 180kDa (dog); ribosome receptor protein
• Gene ID: 6238
• mRNA Refseq: NM_001042576.1
• Protein Refseq: NP_001036041.1
• UniProt ID: Q9P2E9