Recombinant Human RND3, His-tagged

• Cat.No.: RND3-31329TH
• Product Overview: Recombinant full length mature Human RND3 with N terminal His tag; 261aa, 29.2kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 241 amino acids
• Description: Members of the Rho family of Ras-related GTPases, such as ARHE, regulate the organization of the actin cytoskeleton in response to extracellular growth factors. Like Ras (MIM 190020), Rho family members appear to cycle between an inactive GDP-bound form and an active GTP-bound form. Three major regulators of Rho activity have been identified: RhoGDIs, which interact with the GDP-bound Rho proteins to keep them in a resting complex (see MIM 601925); GEFs, which promote GDP/GTP exchange leading to activation of Rho proteins (see MIM 601855); and GAPs, which stimulate GTP hydrolysis and return the activated Rho protein to its inactive form (see MIM 602680) (Nobes et al.
• Conjugation: HIS
• Molecular Weight: 29.200kDa inclusive of tags
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 40% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM EDTA, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSC

Gene Information

• Gene Name: RND3 Rho family GTPase 3 [ Homo sapiens ]
• Official Symbol: RND3
• Synonyms: RND3; Rho family GTPase 3; ARHE, ras homolog gene family, member E; rho-related GTP-binding protein RhoE; Rho8; RhoE
• Gene ID: 390
• mRNA Refseq: NM_005168
• Protein Refseq: NP_005159
• MIM: 602924
• Uniprot ID: P61587
• Chromosome Location: 2q23.3
• Function: GTP binding; GTPase activity; nucleotide binding