Recombinant Human RNASEH2A cell lysate

• Cat.No.: RNASEH2A-1515HCL

Specification

• Description: The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot
• Tag: Non

Gene Information

• Gene Name: RNASEH2A ribonuclease H2, subunit A [ Homo sapiens ]
• Official Symbol: RNASEH2A
• Synonyms: RNASEH2A; ribonuclease H2, subunit A; Aicardi Goutieres syndrome 4 , ribonuclease H2, large subunit; ribonuclease H2 subunit A; AGS4; RNASEHI; RNHIA; RNHL; RNase H(35); RNase H2 subunit A; RNase HI large subunit; ribonuclease HI subunit A; ribonuclease HI large subunit; ribonuclease H2, large subunit; ribonuclease HI, large subunit; aicardi-Goutieres syndrome 4 protein; JUNB
• Gene ID: 10535
• mRNA Refseq: NM_006397
• Protein Refseq: NP_006388
• MIM: 606034
• UniProt ID: O75792
• Chromosome Location: 19p13.13
• Pathway: DNA replication, organism-specific biosystem; DNA replication, conserved biosystem
• Function: RNA binding; endonuclease activity; hydrolase activity; metal ion binding; ribonuclease H activity; ribonuclease activity