Recombinant Human Relaxin 2

• Cat.No.: RLN2-173H
• Product Overview: Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants.
• AA Sequence: A-Chain: QLYSALANKC CHVGCTKRSL ARFC; B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS
• Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
• Biological Activity: Data Not Available
• Note: Research Use Only. Not for use in diagnostic or therapeutic procedures.
• OfficialSymbol: RLN2

Gene Information

• Gene Name: RLN2 relaxin 2 [ Homo sapiens ]
• Synonyms: RLN2; relaxin 2; H2; RLXH2; bA12D24.1.1; bA12D24.1.2; prorelaxin H2; Prorelaxin H2; OTTHUMP00000021027; relaxin 2 (H2); relaxin H2; relaxin, ovarian, of pregnancy; RLXH2; bA12D24.1.1; bA12D24.1.2
• Gene ID: 6019
• mRNA Refseq: NM_005059
• Protein Refseq: NP_005050
• MIM: 179740
• UniProt ID: P04090
• Chromosome Location: 9p24.1
• Pathway: Class A/1 (Rhodopsin-like receptors); GPCR downstream signaling; G alpha (s) signalling events
• Function: hormone activity