Recombinant Human Regulator Of Calcineurin 2, His-tagged
Cat.No. : | RCAN2-6859H |
Product Overview : | Recombinant human RCAN2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. MW: 24.1 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | His |
Protein Length : | 1-197aa |
Description : | RCAN2 belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFAT(nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. RCAN2 is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl. |
Molecular Mass : | 24.1 kDa (217aa), confirmed by MALDI-TOF. |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MPAPSMDCDV STLVACVVDV EVFTNQEVKE KFEGLFRTYD DCVTFQLFKS FRRVRINFSN PKSAARARIE LKLYFAQVQT PETDGDKLHL APPQPAKQFL ISPPSSPPVG WQPINDATPV LNYDLLYAVA KLGPGEKYEL HAGTESTPSV VVHVCDSDIE EEEDPKTSPK PKIIQTRRPG LPPSVSN |
Purity : | >85% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Gene Name | RCAN2 regulator of calcineurin 2 [ Homo sapiens ] |
Official Symbol | RCAN2 |
Synonyms | RCAN2; regulator of calcineurin 2; Down syndrome critical region gene 1 like 1 , DSCR1L1; calcipressin-2; ZAKI 4; Down syndrome candidate region 1-like 1; thyroid hormone-responsive protein ZAKI-4; Down syndrome critical region gene 1-like 1; thyroid hormone-responsive (skin fibroblasts); myocyte-enriched calcineurin-interacting protein 2; CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1; |
Gene ID | 10231 |
mRNA Refseq | NM_001251973 |
Protein Refseq | NP_001238902 |
MIM | 604876 |
UniProt ID | Q14206 |
Chromosome Location | 6p12.3 |
Pathway | Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem; |
Function | nucleotide binding; protein phosphatase 2B binding; |
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◆ Cell & Tissue Lysates | ||
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Not For Human Consumption!
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