Recombinant Human Ras Homolog Gene Family, Member C, His-tagged

• Cat.No.: RHOC-2768H
• Product Overview: Recombinant human RhoC protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 23.8 kDa (210aa).

Specification

• Cat. No.: RHOC-2768H
• Description: RhoC, also known as rho-related GTP-binding protein RhoC, is a small signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases. It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. RhoC promotes reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility.
• Source: E.coli.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl,1mM DTT.
• Purity: > 90% by SDS - PAGE.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVY VPTVFE NYIADIEVDG KQVELALWDT AGQEDYDRLRPLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD LRQDEHTRRE LAKMKQEPVR SEEG RDMANR ISAFGYLECSAKTKEGVREV FEMATRAGLQ VRKNKRRRGC.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Axon guidance; Signaling by GPCR; Signaling by Rho GTPases
• Protein length: 1-190 a.a.

Gene Information

• Gene Name: RHOC ras homolog gene family, member C [ Homo sapiens ]
• Synonyms: ras homolog gene family, member C; H9; ARH9; ARHC; RHOH9; MGC1448; MGC61427; RHOC; rho-related GTP-binding protein RhoC; rhoC GTPase; oncogene RHO H9; rho cDNA clone 9; RAS-related homolog 9; OTTHUMP00000013803; OTTHUMP00000013804; OTTHUMP00000013806; small GTP binding protein RhoC;RhoC; Rho-related GTP-binding protein RhoC; Rho cDNA clone 9; h9
• Gene ID: 389
• mRNA Refseq: NM_001042678
• Protein Refseq: NP_001036143
• MIM: 165380
• UniProt ID: P08134
• Chromosome Location: 1p13.1
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding; signal transducer activity