Recombinant Human RARB

• Cat.No.: RARB-31058TH
• Product Overview: Recombinant fragment corresponding to amino acids 173-409 of Human Retinoic Acid Receptor beta with proprietary tag. Estimated MW 53kDa

Specification

• Species: Human
• Tag: Non
• Protein Length: 173-409 a.a.
• Description: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.
• Biological activity: 1 unit equals 1 nanogram (ng)
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Gene Information

• Gene Name: RARB retinoic acid receptor, beta [ Homo sapiens ]
• Official Symbol: RARB
• Synonyms: RARB; retinoic acid receptor, beta; retinoic acid receptor beta; HAP; NR1B2; RRB2
• Gene ID: 5915
• mRNA Refseq: NM_000965
• Protein Refseq: NP_000956
• MIM: 180220
• Uniprot ID: P10826
• Chromosome Location: 3p24
• Pathway: Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem
• Function: DNA binding; metal ion binding; receptor activity; retinoic acid receptor activity; sequence-specific DNA binding