Recombinant Human RAB5B, Member RAS Oncogene Family, His-tagged

• Cat.No.: RAB5B-3393H
• Product Overview: Recombinant human RAB5B protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques.MW = 26.1 kDa (238aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Ras-related protein Rab-5B, also known as RAB5B, is a member of the Rab family of small (monomeric) G proteins. RAB5B is involved in endocytosis and recycling of cell surface molecules. It interacts with RIN2 and RIN3, which regulate its function, possibly by acting as GEFs. Knockdown of RAB5B abolished group I metabotropic glutamate receptor (mGluR)-mediated neuroprotection.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 0.2M NaCl.
• Purity: > 90% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MGSMTSRSTA RPNGQPQASK ICQFKLVLLG ESAVGKSSLV LRFVKGQFHE YQESTIGAAF LTQSVCLDDT TVKFEIWDTA GQERYHSLAP MYYRGAQAAI VVYDITNQET FARAKTWVKE LQRQASPSIV IALAGNKADL ANKRMVEYEE AQAYADDNSL LFMETSAKTA MNVNDLFLAI AKKLPKSEPQ NLGGAAGRSR GVDLHEQSQQ NKSQCCSN.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Amoebiasis; Endocytosis; Phagosome; Vasopressin-regulated water reabsorption

Gene Information

• Gene Name: RAB5B RAB5B, member RAS oncogene family [ Homo sapiens ]
• Synonyms: RAB5B, member RAS oncogene family;RAB5B; ras-related protein Rab-5B
• Gene ID: 5869
• mRNA Refseq: NM_002868
• Protein Refseq: NP_002859
• MIM: 179514
• UniProt ID: P61020
• Chromosome Location: 12q13
• Function: GTP binding; GTP-dependent protein binding; GTPase activity; nucleotide binding; protein binding