Recombinant Human QPRT, T7-tagged

• Cat.No.: QPRT-2954H
• Product Overview: Recombinant Human QPRT was produced inE.coliwith a T7 tag at N-terminus. MW = 30816 Da (1-297 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: T7
• Protein Length: 1-297 a.a.
• Description: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer"s disease, and Huntington"s disease.
• Form: 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
• Purity: 95%.
• Applications: MS. SDS.

Gene Information

• Gene Name: QPRT quinolinate phosphoribosyltransferase [ Homo sapiens ]
• Synonyms: QPRT; quinolinate phosphoribosyltransferase; QPRTase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; QAPRTase; nicotinate-nucleotide pyrophosphorylase (carboxylating); EC 2.4.2.19; nicotinate-nucleotide pyrophosphorylase
• Gene ID: 23475
• mRNA Refseq: NM_014298
• Protein Refseq: NP_055113
• MIM: 606248
• UniProt ID: Q15274
• Chromosome Location: 16p11.2
• Pathway: Metabolic pathways; Nicotinate and nicotinamide metabolism
• Function: nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity; transferase activity, transferring glycosyl groups