QPRT
-
Official Full Name
quinolinate phosphoribosyltransferase -
Overview
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimers disease, and Huntingtons disease. -
Synonyms
QPRT;quinolinate phosphoribosyltransferase;nicotinate-nucleotide pyrophosphorylase [carboxylating];nicotinate nucleotide pyrophosphorylase (carboxylating);QPRTase;QAPRTase;nicotinate-nucleotide pyrophosphorylase (carboxylating)
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- T7
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
QPRT involved in several pathways and played different roles in them. We selected most pathways QPRT participated on our site, such as Nicotinate and nicotinamide metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with QPRT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PGK2,NNT,ACSM5,DDOST,FDPS,GALNTL5,POLR2EB,MIBP,GPAT2,QDPRB1 |
| Nicotinate and nicotinamide metabolism | NADK2,NADKA,NT5C3L,PNP5A,MIBP2,AOX3,NADSYN1,NT5C1B-RDH14,NT5C3B,NT5C1AA |
Protein Function
QPRT has several biochemical functions, for example, nicotinate-nucleotide diphosphorylase (carboxylating) activity,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by QPRT itself. We selected most functions QPRT had, and list some proteins which have the same functions with QPRT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nicotinate-nucleotide diphosphorylase (carboxylating) activity | NAMPTB,KCNG4,NAMPT,NAPRT,NAPRT1 |
| protein homodimerization activity | ADRB3,PDGFB,SMAD2,IRF3,TFAP2B,FAM109A,DLK2,USH2A,SNX1,GDNFA |
Interacting Protein
QPRT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with QPRT here. Most of them are supplied by our site. Hope this information will be useful for your research of QPRT.
GIT2;KRTAP4-12;SUFU
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