Recombinant Human QPRT, His-tagged

• Cat.No.: QPRT-30232TH
• Product Overview: Recombinant full length Human QPRT with a N terminal His tag; 317aa inclusive of tag, 32.9 kDa.

Specification

• Description: This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimers disease, and Huntingtons disease.
• Protein length: 297 amino acids
• Conjugation: HIS
• Molecular Weight: 32.900kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: 0% NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
• Sequence Similarities: Belongs to the nadC/modD family.

Gene Information

• Gene Name: QPRT quinolinate phosphoribosyltransferase [ Homo sapiens ]
• Official Symbol: QPRT
• Synonyms: QPRT; quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase [carboxylating]; nicotinate nucleotide pyrophosphorylase (carboxylating); QPRTase
• Gene ID: 23475
• mRNA Refseq: NM_014298
• Protein Refseq: NP_055113
• MIM: 606248
• Uniprot ID: Q15274
• Chromosome Location: 16p11.2
• Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of vitamins and cofactors, organism-specific biosystem; Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem; Nicotinate and nicotinamide metabolism, organism-specific biosystem
• Function: nicotinate-nucleotide diphosphorylase (carboxylating) activity; protein homodimerization activity