Recombinant Human QPCT Protein (Val29-Leu361), His tagged

Description :	Glutaminyl cyclase, also known as QPCT, can promote the N-terminal cyclization reaction of N-terminal pyroglutamate (pGlu). The pGlu formation from its glutaminyl precursor is required in the maturation of numerous bioactive peptides, while the aberrant formation of pGlu may be related to several pathological processes, such as osteoporosis and amyloidotic diseases. Glutaminyl cyclase's structure reveals an alpha/beta scaffold akin to that of two-zinc exopeptidases but with several insertions and deletions, particularly in the active-site region. Glutaminyl cyclase's amino acid sequence of this enzyme is 86 % identical to that of bovine glutaminyl cyclase. It is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides.
Source :	E. coli
Species :	Human
Tag :	His
Form :	Lyophilized powder/frozen liquid
Molecular Mass :	37.96 kDa
Protein length :	Val29-Leu361
Purity :	> 90 % as determined by SDS-PAGE
Notes :	For research use only.
Storage :	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
Storage Buffer :	Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
Reconstitution :	Reconstitute in sterile water for a stock solution.
Shipping :	They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Name	QPCT glutaminyl-peptide cyclotransferase [ Homo sapiens (human) ]
Official Symbol	QPCT
Synonyms	QPCT; glutaminyl-peptide cyclotransferase; GCT; glutaminyl cyclase; QC; EC; glutamyl cyclase; glutaminyl-tRNA cyclotransferase; sQC;
Gene ID	25797
mRNA Refseq	NM_012413
Protein Refseq	NP_036545
MIM	607065
UniProt ID	Q16769