Recombinant Human PYCR1, His-tagged

• Cat.No.: PYCR1-31273TH
• Product Overview: Recombinant full length Human PYCR1 protein with an N terminal His tag. Predicted MWt: 34 kDa

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.
• Conjugation: HIS
• Form: Lyophilised:Reconstitute with 57 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLA TVSALRKMGVKLTPHNKETVQHSDVLFLAVKPHIIPFI LDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPR VIRCMTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSV GFCTEVEEDLIDAVTGLSGSGPAYAFTALDALADGGVK MGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVS SPGGATIHALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTALSPSGHTKLLP RSLAPAGKD
• Full Length: Full L.

Gene Information

• Gene Name: PYCR1 pyrroline-5-carboxylate reductase 1 [ Homo sapiens ]
• Official Symbol: PYCR1
• Synonyms: PYCR1; pyrroline-5-carboxylate reductase 1; pyrroline-5-carboxylate reductase 1, mitochondrial; P5C
• Gene ID: 5831
• mRNA Refseq: NM_006907
• Protein Refseq: NP_008838
• MIM: 179035
• Uniprot ID: P32322
• Chromosome Location: 17
• Pathway: Amino acid synthesis and interconversion (transamination), organism-specific biosystem; Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem
• Function: identical protein binding; nucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; pyrroline-5-carboxylate reductase activity