Recombinant Human PTPRG

• Cat.No.: PTPRG-30355TH
• Product Overview: Recombinant fragment, corresponding to amino acids 801-1147 of Human PTP gamma, containing the catalytic domain and with an N terminal properitary tag. M.Wt 65 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 801-1147 a.a.
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.
• Tissue specificity: Found in a variety of tissues.
• Biological activity: 10 U/ug. One unit will hydrolyze 1 nmol p-nitrophenyl phosphateper minute at pH 7.4 and 30C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3mM DTT, 100 mM NaCl, 50 mM pNPP.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 75mM Sodium chloride, 25mM Tris HCl, 2mM EDTA, 10mM Glutathione, 1mM DTT, pH 8.0
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.Contains 1 alpha-carbonic anhydrase domain.Contains 1 fibronectin type-III domain.Contains 2 tyrosine-protein phosphatase domains.

Gene Information

• Gene Name: PTPRG protein tyrosine phosphatase, receptor type, G [ Homo sapiens ]
• Official Symbol: PTPRG
• Synonyms: PTPRG; protein tyrosine phosphatase, receptor type, G; PTPG; receptor-type tyrosine-protein phosphatase gamma; RPTPG
• Gene ID: 5793
• mRNA Refseq: NM_002841
• Protein Refseq: NP_002832
• MIM: 176886
• Uniprot ID: P23470
• Chromosome Location: 3p21-p14
• Function: hydrolase activity; identical protein binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity