Recombinant Human PTPRF, GST-tagged, Active

• Cat.No.: PTPRF-469H
• Product Overview: Recombinant human PTPRF (1275-1897) was expressed inE.Coliusing an N-terminal GST tag. MW=93kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1275-1897 a.a.
• Description: PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
• Sequence: 1275-1897.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• 22q13.33: 1p34

Gene Information

• Gene Name: PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
• Synonyms: PTPRF; protein tyrosine phosphatase, receptor type, F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; LAR; FLJ43335; FLJ45062; FLJ45567; EC 3.1.3.48
• Gene ID: 5792
• mRNA Refseq: NM_002840
• Protein Refseq: NP_002831
• MIM: 179590
• UniProt ID: P10586
• Pathway: Adherens junction; Cell adhesion molecules (CAMs); Insulin signaling pathway
• Function: heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity