Recombinant Human PTPRF, Catalytic Domain

Cat. No. :	PTPRF-714H
Description :	PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance.
Source :	E.Coli.
Biochem/Physiol Actions :	LAR, a leukocyte antigen related protein, is a transmembrane receptor-like protein tyrosine phosphatase (PTPase). Its cytoplasmic domain comprises two tandem domains possessing PTPase homology. Only one domain, LAR-D1, has phosphatase activity.
Analysis Note :	LAR-D1 catalytic domain comprises amino acids 1275-1613.
Physical Form :	Solution containing 10 mM imidazole, pH 7.0, 2 mM EDTA, 5 mM DTT, 0.1 M NaCl, and 50% glycerol.
Assay :	≥95% (SDS-PAGE).
Form :	Buffered aqueous glycerol solution.
Storage Temp :	−70°C.
Tag :	Non

Gene Name	PTPRF protein tyrosine phosphatase, receptor type, F [ Homo sapiens ]
Synonyms	PTPRF; protein tyrosine phosphatase, receptor type, F; LCA-homolog; OTTHUMP00000008683; OTTHUMP00000008684; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; protein tyrosine phosphatase, receptor type, F polypeptide; receptor-linked protein-tyrosine phosphatase LAR; LAR; FLJ43335; FLJ45062; FLJ45567; EC 3.1.3.48
Gene ID	5792
mRNA Refseq	NM_002840
Protein Refseq	NP_002831
MIM	179590
UniProt ID	P10586
Chromosome Location	1p34
Pathway	Adherens junction; Cell adhesion molecules (CAMs); Insulin signaling pathway
Function	heparan sulfate proteoglycan binding; heparin binding; hydrolase activit; protein binding; protein kinase binding; transmembrane receptor protein tyrosine phosphatase activity