Recombinant Human PTPN7

• Cat.No.: PTPN7-26538TH
• Product Overview: Recombinant fusion protein, corresponding to amino acids 79-358 of Human HePTP / PTPN7.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 79-358 a.a.
• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene.
• Tissue specificity: Expressed exclusively in thymus and spleen.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 45% Glycerol, 50mM Tris HCl (pH 8.0), 5mM DTT, 5mM Reduced Glutathione, 150mM Sodium Chloride.
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: Fusion protein comprising amino acids 79-358 of HePTP, tagged at the N-terminus with GST.
• Sequence Similarities: Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.Contains 1 tyrosine-protein phosphatase domain.

Gene Information

• Gene Name: PTPN7 protein tyrosine phosphatase, non-receptor type 7 [ Homo sapiens ]
• Official Symbol: PTPN7
• Synonyms: PTPN7; protein tyrosine phosphatase, non-receptor type 7; tyrosine-protein phosphatase non-receptor type 7; HEPTP; LC PTP
• Gene ID: 5778
• mRNA Refseq: NM_001199797
• Protein Refseq: NP_001186726
• MIM: 176889
• Uniprot ID: P35236
• Chromosome Location: 1q32.1
• Pathway: Downstream signaling in naive CD8+ T cells, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, organism-specific biosystem; MAPK signaling pathway, conserved biosystem; Ras signaling in the CD4+ TCR pathway, organism-specific biosystem
• Function: hydrolase activity; protein tyrosine phosphatase activity