PTPN7
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Official Full Name
protein tyrosine phosphatase, non-receptor type 7 -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
PTPN7;protein tyrosine phosphatase, non-receptor type 7;tyrosine-protein phosphatase non-receptor type 7;HEPTP;LC PTP;BPTP 4;BPTP4;Dual specificity phosphatase 1;Hematopoietic protein tyrosine phosphatase;Hematopoietic protein-tyrosine phosphatase;LCPTP;LPTP;Protein tyrosine phoshatase non receptor type stress induced;Protein tyrosine phoshatase nonreceptor type stress induced;Protein tyrosine phosphatase LC PTP;Protein tyrosine phosphatase non receptor type 7;Protein-tyrosine phosphatase LC-PTP;PTN7_HUMAN;PTPN 7;PTPNI;Tyrosine protein phosphatase non receptor type 7;protein-tyrosine phosphatase, nonreceptor-type, stress induced;BPTP-4;LC-PTP
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- Non
- His
- His&T7
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTPN7-2058H | Recombinant Human PTPN7, GST-tagged | E.coli | Human | GST | 1-399aa | |
| PTPN7-26537TH | Recombinant Human PTPN7 | E.coli | Human | Non | Full L. |
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| PTPN7-26538TH | Recombinant Human PTPN7 | E.coli | Human | Non | 79-358 a.a. |
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| PTPN7-466H | Recombinant Human PTPN7,GST-tagged,Active | E.coli | Human | GST | Full L. |
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| PTPN7-4836R | Recombinant Rat PTPN7 Protein | Mammalian Cells | Rat | His |
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| PTPN7-8094H | Recombinant Human PTPN7 protein, His & T7-tagged | E.coli | Human | His&T7 | Pro52~Glu314 |
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| PTPN7-2680HCL | Recombinant Human PTPN7 293 Cell Lysate | HEK293 | Human | Non |
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| PTPN7-2681HCL | Recombinant Human PTPN7 293 Cell Lysate | HEK293 | Human | Non |
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| PTPN7-4495R | Recombinant Rat PTPN7 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PTPN7-4495R-B | Recombinant Rat PTPN7 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| PTPN7-4695H | Recombinant Human PTPN7 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Ptpn7-5242M | Recombinant Mouse Ptpn7 Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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Involved Pathway
PTPN7 involved in several pathways and played different roles in them. We selected most pathways PTPN7 participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RPS6KAL,FGF21,NR4A1,MAPK10,ATF4B1,GRB2A,STMN1,PPP3R1B,FGF12,ECSIT |
Protein Function
PTPN7 has several biochemical functions, for example, protein binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN7 itself. We selected most functions PTPN7 had, and list some proteins which have the same functions with PTPN7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein tyrosine phosphatase activity | CDKN3,DUSP22B,MTMR8,PTPDC1,EYA4,EYA1,DNAJC6,MTMR1A,CDC25A,PTPRF |
| protein binding | STXBP3A,STMN1,NT5C2,ACOT8,AHSP,TNIP3,WBP2,MAP2K7,CRCT1,ZC3H14 |
Interacting Protein
PTPN7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN7.
MAPK1;MAPK14;CCDC57;FLJ13057;CDH2;Mapk14
Resources
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References
- Gonzalez-Fernandez, L; Ortega-Ferrusola, C; et al. Identification of Protein Tyrosine Phosphatases and Dual-Specificity Phosphatases in Mammalian Spermatozoa and Their Role in Sperm Motility and Protein Tyrosine Phosphorylation. BIOLOGY OF REPRODUCTION 80:1239-1252(2009).
