Recombinant Human PTK2

• Cat.No.: PTK2-28820TH
• Product Overview: Recombinant full length Human FAK with N-terminal proprietary tag, 140kDa.

Specification

• Description: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined.
• Protein length: 1052 amino acids
• Molecular Weight: 140.000kDa
• Source: Baculovirus infected sf9 cells
• Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.
• Biological activity: The Specific activity of PTK2-28820TH was determined to be 28 nmol/min/mg.
• Form: Liquid
• Purity: by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 0.01% Triton-X-100, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain.
• Tag: Non

Gene Information

• Gene Name: PTK2 PTK2 protein tyrosine kinase 2 [ Homo sapiens ]
• Official Symbol: PTK2
• Synonyms: PTK2; PTK2 protein tyrosine kinase 2; focal adhesion kinase 1; FADK; FAK; FAK1; PPP1R71; protein phosphatase 1; regulatory subunit 71
• Gene ID: 5747
• mRNA Refseq: NM_001199649
• Protein Refseq: NP_001186578
• MIM: 600758
• Uniprot ID: Q05397
• Chromosome Location: 8q24.3
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem
• Function: ATP binding; JUN kinase binding; SH2 domain binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding