Recombinant Human Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme, His-tagged

• Cat.No.: PPP1CC-2401H
• Product Overview: Recombinant humanPPP1CC protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: PPP1CC, also knownas serine/threonine-protein phosphatase PP1-gamma catalytic subunit, isessential for cell division, and participates in the regulation of glycogenmetabolism, muscle contractility and protein synthesis. This protein isinvolved in regulation of ionic conductances and long-term synapticplasticity and may play an important role in dephosphorylating substratessuch as the postsynaptic density-associated Ca2+/calmodulin dependent proteinkinase II
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 50% glycerol, 0.2M NaCl, 2mM DTT
• Molecular Weight: 39.1 kDa (343aa),confirmed by MALDI-TOF
• Purity: > 85% by SDS -PAGE
• Concentration: 0.25 mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLKICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL LRGNHECASINRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL QSMEQIRRIM RPTDVPDQGLLCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD LDLICRAHQV VEDGYEFFAK RQLVTLFSAPNYCGEFDNAG AMMSVDETLM CSFQILKPAE KKKPNATRPV TPPRGMITKQ AKK
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PPP1CC protein phosphatase 1,catalytic subunit, gamma isozyme [ Homo sapiens ]
• Official symbol: PPP1CC
• Synonyms: PPP1CC; protein phosphatase 1,catalytic subunit, gamma isozyme; PPP1G; PP1gamma; erine/threonine-proteinphosphatase PP1-gamma catalytic subunitPP-1G; serine/threonine phosphatase1 gamma; protein phosphatase 1C catalytic subunit; protein phosphatase 1,catalytic subunit, gamma isoform; EC 3.1.3.16
• Gene ID: 5501
• mRNA Refseq: NM_002710
• Protein Refseq: NP_002701
• MIM: 176914
• UniProt ID: P36873
• Chromosome Location: 12q24.1-q24.2
• Pathway: Focal adhesion; Insulin signalingpathway; Long-term potentiation; Oocyte meiosis; Regulation of actin cytoskeleton;Vascular smooth muscle contraction
• Function: hydrolase activity; metal ionbinding; protein binding; protein kinase binding; protein serine/threoninephosphatase activity