Recombinant Human Proteasome (Prosome, Macropain) Activator Subunit 2 (PA28 Beta), His-tagged

• Cat.No.: PSME2-1288H
• Product Overview: Recombinant human PSME2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Specification

• Cat. No.: PSME2-1288H
• Description: PSME2, also known as proteasome (prosome, macropain) activator subunit 2, is an IFN-gamma inducible proteasome activator required for presentation of certain major histocompatibility (MHC) class I antigens. Downregulation of PSME2 results in abnormal proteasome activation and has been implicated in the development of intimal hyperplasia (IH) in animal models.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 0.1M NaCl,1mM DTT, 0.1mM PMSF
• Molecular Weight: 29.5 kDa (259aa), confirmed by MALDI-TOF
• Purity: > 95% by SDS - PAGE
• Concentration: 1.0 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: APC/C:Cdc20 mediated degradation of mitotic proteins; Antigen processing: Ubiquitination & Proteasome degradation; Apoptosis; Cell Cycle; DNA Replication Pre-Initiation

Gene Information

• Gene Name: PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [ Homo sapiens ]
• Official Symbol: PSME2
• Synonyms: PSME2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); PA28B; REGbeta; PA28beta; proteasome activator complex subunit 2; REG-beta; OTTHUMP00000027977; MCP activator, 31-kD subunit; proteasome activator 28-beta; 11S regulator complex beta subunit; 11S regulator complex subunit beta; cell migration-inducing protein 22; proteasome activator 28 subunit beta; proteasome activator hPA28 subunit beta; activator of multicatalytic protease subunit 2; Proteasome activator complex subunit 2; 11S regulator complex subunit beta; Proteasome activator 28 subunit beta; Activator of multicatalytic protease subunit 2; PA28b
• Gene ID: 5721
• mRNA Refseq: NM_002818
• Protein Refseq: NP_002809
• MIM: 602161
• UniProt ID: Q9UL46
• Chromosome Location: 14q11.2