PSME2
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Official Full Name
proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008] -
Synonyms
PSME2;proteasome (prosome, macropain) activator subunit 2 (PA28 beta);PA28B;REGbeta;PA28beta;proteasome activator complex subunit 2;REG-beta;MCP activator, 31-kD subunit;proteasome activator 28-beta;11S regulator complex beta subunit;11S regulator complex subunit beta;cell migration-inducing protein 22;proteasome activator 28 subunit beta;proteasome activator hPA28 subunit beta;activator of multicatalytic protease subunit 2
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Mouse
- Human
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
PSME2 involved in several pathways and played different roles in them. We selected most pathways PSME2 participated on our site, such as Proteasome,Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSME2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteasome | PSMC4,PSMC5,IFNG,PSMD4A,PSMB3,PSMB9A,PSMB8,PSMD1,PSMC1B,PSME1 |
| Antigen processing and presentation | RFXAP,HSPA5,HLA-A,CD8B,HLA-E,KIR2DS4,RFXANK,LGMN,HLA-DPB1,CTSL1 |
Protein Function
PSME2 has several biochemical functions, for example, endopeptidase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSME2 itself. We selected most functions PSME2 had, and list some proteins which have the same functions with PSME2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activator activity | PSMD14,PSME1,SFRP2,ADRM1,PSME3 |
Interacting Protein
PSME2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSME2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSME2.
IKBKE;MYOD1;EPHA2;NHLH1;PSME1;q5nf52_fratt;putA;prsA;oppF;sucA;aer;groL;Psmb5;CFTR;NAA10;SHFM1;Psmb4
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References
- Milioli, HH; Sousa, KS; et al. Comparative Proteomics of Primary Breast Carcinomas and Lymph Node Metastases Outlining Markers of Tumor Invasion. CANCER GENOMICS & PROTEOMICS 12:89-101(2015).
- Ferreira, GB; Baeke, F; et al. A proteomic approach on the effects of TX527, a 1 alpha,25-dihydroxyvitamin D-3 analog, in human T lymphocytes. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 144:96-101(2014).
