Recombinant Human PROCR protein, Fc-tagged

• Cat.No.: PROCR-8575H
• Product Overview: Recombinant Human PROCR (Ser18-Thr209) protein was fused to human IgG1 Fc tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: Ser18-Thr209
• Description: Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR/EPCR/CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR/EPCR/CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.
• Predicted N Terminal: Ser18
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 48.6 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: PROCR
• Official Symbol: PROCR
• Synonyms: PROCR; protein C receptor, endothelial; endothelial protein C receptor; CCD41; CD201; EPCR; APC receptor; centrocyclin; CD201 antigen; activated protein C receptor; endothelial cell protein C receptor; cell cycle, centrosome-associated protein; CCCA; bA42O4.2; MGC23024
• Gene ID: 10544
• mRNA Refseq: NM_006404
• Protein Refseq: NP_006395
• MIM: 600646
• UniProt ID: Q9UNN8