Recombinant Human PRKAA2 protein, His/MBP-tagged

• Cat.No.: PRKAA2-364H
• Product Overview: Recombinant Human PRKAA2(252-321 aa) fused with His/MBP tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
• Source: E. coli
• Species: Human
• Tag: His&MBP
• Form: Liquid in PBS
• Protein length: 252-321 aa
• Purity: SDS-PAGE >90%
• Applications: WB Positive Control
• Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
• Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit [ Homo sapiens ]
• Official Symbol: PRKAA2
• Synonyms: PRKAA2; protein kinase, AMP-activated, alpha 2 catalytic subunit; PRKAA; 5-AMP-activated protein kinase catalytic subunit alpha-2; AMPK; AMPKa2; AMPK-alpha-2 chain; AMPK subunit alpha-2; 5-AMP-activated protein kinase, catalytic alpha-2 chain; AMPK2
• Gene ID: 5563
• mRNA Refseq: NM_006252
• Protein Refseq: NP_006243
• MIM: 600497
• UniProt ID: P54646