PRKAA2
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Official Full Name
protein kinase, AMP-activated, alpha 2 catalytic subunit -
Overview
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a;heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important;energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is;activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy;beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and;cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin;sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. -
Synonyms
PRKAA2;protein kinase, AMP-activated, alpha 2 catalytic subunit;PRKAA;5-AMP-activated protein kinase catalytic subunit alpha-2;AMPK;AMPKa2;AMPK-alpha-2 chain;AMPK subunit alpha-2;5-AMP-activated protein kinase, catalytic alpha-2 chain;AMPK2
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Sf9 Cells
- Mammalian Cells
- Sf21 Cells
- HEK293
- His
- GST
- MBP
- Non
- Avi
- Fc
Involved Pathway
PRKAA2 involved in several pathways and played different roles in them. We selected most pathways PRKAA2 participated on our site, such as FoxO signaling pathway,Regulation of autophagy,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| FoxO signaling pathway | TGFB3,FOXO3A,GADD45BA,PLK4,IKBKB,FOXO1,FOXG1,RBL2,NRAS,SMAD4 |
| Oxytocin signaling pathway | PLA2G4A,PPP3CB,CD38,CACNG1,PRKACB,CALM1,MYL6,GNAS,PIK3R5,HRAS |
| Regulation of autophagy | ATG4C,IFNA21,PIK3C3,INS2,IFNA5,IFNPHI3,ULK3,INS,ATG4B,ATG10 |
| Non-alcoholic fatty liver disease (NAFLD) | TNFRSF1A,NDUFA4,SREBF1,PKLR,COX5A,ATF4,CEBPA,ADIPOR2,ITCH,NDUFS3 |
| Insulin resistance | PTPN11B,PPP1CB,PIK3CG,RPS6KA6,CREB3L3A,G6PCA.1,IL6,PPP1CAB,PRKAG3,NR1H3 |
| Insulin signaling pathway | PIK3R3B,TSC1,INPPL1A,TSC2,CALM1B,BAD,CALM4,INPPL1,GRB2B,PRKACAA |
| PIK-Akt signaling pathway | IL3RA,AKT2,PIK3CG,VEGFC,FGF10,THBS1,SOS1,Gh,YWHAB,Ifna11 |
| Circadian rhythm | RORA,CLOCK,FBXW11,CRY2,PRKAG2,PRKAA1,PRKAG3,FBXL3,BTRC,PRKAG1 |
| mTOR signaling pathway | TSC1B,MTOR,EIF4E1C,PRKCBA,TSC1,CAB39L,PRKCB,IRS1,PIK3CG,PDPK1B |
Protein Function
PRKAA2 has several biochemical functions, for example, AMP-activated protein kinase activity,ATP binding,[acetyl-CoA carboxylase] kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAA2 itself. We selected most functions PRKAA2 had, and list some proteins which have the same functions with PRKAA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ROCK1,ACSL5,Ckmm,BMPR2A,HSC70,OAS2,ABCC9,UBE2QL1,LIMK2,ITGB1BP3 |
| protein binding | MS4A1,TMEM51,OOEP,MICAL1,TMEM173,TAF6,MPP7,RNF20,ARL16,RAB1 |
| chromatin binding | POU2F1,WACA,CDK9,HHEX,NSBP1,CBX4,POLR2B,REL,POU1F1,ATF2 |
| [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity | PRKAA1 |
| protein kinase activity | PRKAA1,DYRK1B,PINK1,NAT1,Aatk,FGFR1B,HIPK3B,EPHA4A,PDK1,LIMK1A |
| protein serine/threonine/tyrosine kinase activity | AURKB,ACVR2B,SGK1,DYRK2,AURKA,DSTYK,DYRK1AA,RPS6KB1,DYRK3,DYRK1A |
| AMP-activated protein kinase activity | PRKAA1,PRKAB1,ALPK2,PRKAG3,PRKAG2 |
| histone serine kinase activity | AURKC,AURKB,PRKAA1,ATM,AURKA |
| [acetyl-CoA carboxylase] kinase activity | PRKAA1 |
Interacting Protein
PRKAA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAA2.
PRKAB2;PRKAG1;KIFC3;386682
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References
- Bhavsar, SK; Schmidt, S; et al. AMPK alpha 1-Sensitivity of Orai1 and Ca2+ Entry in T-Lymphocytes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 32:687-698(2013).
- Voss, M; Paterson, J; et al. Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. CELLULAR SIGNALLING 23:114-124(2011).
