Recombinant Human Pregnane X receptor LBD/Hsp90 complex, GST-tagged

• Cat.No.: NR1I2-107H
• Product Overview: Recombinant Human GST-tagged Pregnane X receptor ligand-binding domain (PXR-LBD) consists of a 218 a.a. GST tag, a 14 a.a. flexible linker and a 233 a.a. PXR, NR1I2 ligand binding domain, Acc# AAH17304.2, amino acids 201-433. Human Pregnane X receptor ligand-binding domain (PXR-LBD) in complex with human Hsp90 was produced in insect cells co-infected with two recombinant baculoviruses. GST tagged PXR-LBD, Hsp90 and Hsc70 are the major components of the complex.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Form: 20 mM Na-P pH 8.0, 40 mM KCl, 20 mM Na2MoO4, 7 mM reduced glutathione, 15% glycerol.
• Purity: >90%
• Applications: Ligand binding and coactivator peptide recruitment assays.
• Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.

Gene Information

• Gene Name: NR1I2 nuclear receptor subfamily 1, group I, member 2 [ Homo sapiens ]
• Official Symbol: NR1I2
• Synonyms: NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X nuclear receptor variant 2; PAR; PRR; SAR; PAR1; PARq
• Gene ID: 8856
• mRNA Refseq: NM_003889
• Protein Refseq: NP_003880
• MIM: 603065
• UniProt ID: O75469
• Chromosome Location: 3q12-q13.3
• Pathway: Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem
• Function: drug binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription coactivator activity; zinc ion binding