NR1I2
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Official Full Name
nuclear receptor subfamily 1, group I, member 2 -
Overview
PXR (also known as orphan nuclear receptor PXR, pregnane X receptor, orphan nuclear receptor PAR1, and steroid and xenobiotic receptor (SXR)) is a member of the nuclear hormone receptor family, NR1 subfamily containing a zinc finger domain. Alternatively -
Synonyms
NR1I2;nuclear receptor subfamily 1, group I, member 2;nuclear receptor subfamily 1 group I member 2;BXR;ONR1;PAR2;PXR;SXR;pregnane X receptor;orphan nuclear receptor PXR;orphan nuclear receptor PAR1;steroid and xenobiotic receptor;pregnane X n
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- E.coli
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- Sf21 Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- GST
- Myc
- SUMO
- Flag
- Avi
- Fc
- DDK
Involved Pathway
NR1I2 involved in several pathways and played different roles in them. We selected most pathways NR1I2 participated on our site, such as Drug Induction of Bile Acid Pathway,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Generic Transcription Pathway | JUNB,ZNF558,ZNF706,ZNF584,ZNF75D,PPARAA,CDK8,NR6A1A,ZNF549,SKI |
| Gene Expression | ZFP143,NR2C2,ZNF433,IGF2BP3,SUPT4H1,ZNF621,ZNF726,ZNF10,NR2E1,ZNF529 |
| Drug Induction of Bile Acid Pathway | SLCO1B1,NR1I3,CYP7A1,SLC51B,ABCC2 |
| Nuclear receptors in lipid metabolism and toxicity | RARG,VDRB,CYP27B1,ABCC2,NR1I3,CYP24A1,RARGB,CYP26A1,RARGA |
| Nuclear Receptors | NR2F1,NR1I3,NR1D2B,NR0B1,RORAA,ROR1,VDRB,NR2F1A,RARGA,NR5A1 |
| Nuclear Receptor transcription pathway | NRBF2,ESRRGA,NR2F6A,ESR2B,NR1D2A,NR2C2,NR2F1,NR4A2B,RARGA,NR1H3 |
Protein Function
NR1I2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1I2 itself. We selected most functions NR1I2 had, and list some proteins which have the same functions with NR1I2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | GLIS1,ARHGAP35,CGGBP1,GATA2A,EAF2,SKINT8,XBP1,CREB3,ZNF480,NHLH1 |
| steroid hormone receptor activity | NR2E3,ESRRB,PPARD,VDRA,NR2F1B,NR2F1A,RXRAB,NR2F6,PPARAA,RARG |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | BARX1,CREB3L3,ATF2,GATA2B,GATA3,FOXC1,ATF5,HIF1A,STAT3,TRPS1 |
| protein binding | RHPN1,RDBP,SYT11,PLEC,MTOR,CCT5,FIP1L1,PRKCQ,GBF1,GNB5 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | NR2F2,RXRA,NR4A2,RXRB,NR5A5,PPARD,Ar,NR1H3,NR0B1,NR5A1A |
| zinc ion binding | ZNF346,TRIM50,BTR12,L3MBTL1,CAR5A,PHF3,ZMAT3,PDLIM3B,LHX8,SIRT6 |
| transcription coactivator activity | MAML1,HCFC2,RNF14,YAF2,ACTL6B,MED26,MED1,SERTAD2,CTBP2,GABPA |
| drug binding | MT2A,PPP3CB,HTR2C,CHKA,CHRNA2,PDXK,DCK,FOLR1,DRD3,TLR7 |
Interacting Protein
NR1I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1I2.
HSP90AB1;pxr-re_consensus_dna-probe;Sirt1;Ppargc1a;FGR;MAPK7;NFATC4;ATP6AP1;TFAP2C;SDF4;cp2c8_human_dr5-site_dna-probe
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References
- Huang, Q; Xue, JL; et al. NR4A1 is associated with chronic low-grade inflammation in patients with type 2 diabetes. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1648-1654(2014).
- Xiao, SS; Zhou, YH; et al. CD44 affects the expression level of FOS-like antigen 1 in cervical cancer tissues. MOLECULAR MEDICINE REPORTS 9:1667-1674(2014).
