Recombinant Human PPP1R14A, His-tagged

• Cat.No.: PPP1R14A-27585TH
• Product Overview: Recombinant full length, Human CPI17 alpha (amino acids 1-147) with N terminal His tag; 167 amino acids, with a predicted MWt 18 kDa including tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 147 amino acids
• Description: The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
• Conjugation: HIS
• Molecular Weight: 18.000kDa inclusive of tags
• Tissue specificity: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.06% EDTA, 0.02% DTT, 10% Glycerol
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MAAQRLGKRV LSKLQSPSRA RGPGGSPGGL QKRHARVTVK YDRRELQRRL DVEKWIDGRL EELYRGMEAD MPDEINIDEL LELESEEERS RKIQGLLKSC GKPVEDFIQE LLAKLQGLHR QPGLRQPSPS HDGSLSPLQD RARTAHP
• Sequence Similarities: Belongs to the PP1 inhibitor family.

Gene Information

• Gene Name: PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A [ Homo sapiens ]
• Official Symbol: PPP1R14A
• Synonyms: PPP1R14A; protein phosphatase 1, regulatory (inhibitor) subunit 14A; PPP1INL; protein phosphatase 1 regulatory subunit 14A; 17 kDa PKC potentiated inhibitory protein of PP1; 17 KDa protein; CPI 17; PKC potentiated inhibitory protein of PP1
• Gene ID: 94274
• mRNA Refseq: NM_001243947
• Protein Refseq: NP_001230876
• MIM: 608153
• Uniprot ID: Q96A00
• Chromosome Location: 19q13.1
• Pathway: Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem
• Function: protein phosphatase inhibitor activity