Recombinant Human PPARG, His-tagged

• Cat.No.: PPARG-31034TH
• Product Overview: Recombinant fragment, corresponding to amino acids 204-477 of His tagged Human PPAR gamma. Predicted MW 31 kDa,

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 204-477 a.a.
• Description: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
• Conjugation: HIS
• Tissue specificity: Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.
• Biological activity: PPARG-31034TH has been tested in a SRC1 interaction assay and has been found to be ligand dependent.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain.

Gene Information

• Gene Name: PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ]
• Official Symbol: PPARG
• Synonyms: PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma
• Gene ID: 5468
• mRNA Refseq: NM_005037
• Protein Refseq: NP_005028
• MIM: 601487
• Uniprot ID: P37231
• Chromosome Location: 3p25
• Pathway: Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem
• Function: DNA binding; activating transcription factor binding; arachidonic acid binding; drug binding; enzyme binding