Recombinant Human PPARG
Cat.No. : | PPARG-28671TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 1-477 of Human PPAR gamma, Predicted MWt 54 kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | 1-477 a.a. |
Description : | This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. |
Tissue specificity : | Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. |
Gene Name | PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ] |
Official Symbol | PPARG |
Synonyms | PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma; |
Gene ID | 5468 |
mRNA Refseq | NM_005037 |
Protein Refseq | NP_005028 |
MIM | 601487 |
Uniprot ID | P37231 |
Chromosome Location | 3p25 |
Pathway | Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; |
Function | DNA binding; activating transcription factor binding; arachidonic acid binding; drug binding; enzyme binding; |
◆ Recombinant Proteins | ||
PPARG-1838HFL | Recombinant Full Length Human PPARG Protein, C-Flag-tagged | +Inquiry |
PPARG-1103C | Recombinant Chicken PPARG | +Inquiry |
PPARG-5498H | Recombinant Human PPARG protein, His-tagged | +Inquiry |
PPARG-1872H | Recombinant Human PPARG, GST-tagged | +Inquiry |
PPARG-1091H | Recombinant Human PPARG, Ligand Binding Domain, GST-tagged | +Inquiry |
◆ Cell & Tissue Lysates | ||
PPARG-492HCL | Recombinant Human PPARG cell lysate | +Inquiry |
Not For Human Consumption!
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