Recombinant Human PPARG, 1-477aa, His-tagged

• Cat.No.: PPARG-68H
• Product Overview: Recombinant Humanperoxisome proliferator-activated receptor gamma encoding amino acids 1-477 expressed inE.coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-477 a.a.
• Description: Peroxisome proliferators are non-genotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family termed peroxisome proliferators activated receptors (PPARs). Nuclear hormone receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids.
• Amino Acid Sequence: MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLYZ.
• Physical Appearance: Sterile Filtered clear solution.
• Formulation: PPAR-g protein at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Applications: •ELISA•Inhibition Assays •Western Blotting.
• Characterization: PPAR-g antibody reactive.

Gene Information

• Gene Name: PPARG peroxisome proliferator-activated receptor gamma [ Homo sapiens ]
• Synonyms: PPARG; peroxisome proliferator-activated receptor gamma; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma;Peroxisome proliferator-activated receptor gamma;Nuclear receptor subfamily 1 group C member 3; peroxisome proliferative activated receptor, gamma; peroxisome proliferative activated receptor gamma; peroxisome proliferator-activated receptor gamma 1; OTTHUMP00000185030; OTTHUMP00000185033; OTTHUMP00000185037
• Gene ID: 5468
• mRNA Refseq: NM_005037
• Protein Refseq: NP_005028
• UniProt ID: P37231
• Chromosome Location: 3p25
• MIM: 601487
• Pathway: Huntington"s disease; PPAR signaling pathway; Pathways in cancer
• Function: arachidonic acid binding; drug binding; metal ion binding; prostaglandin receptor activity; prostaglandin receptor activity; protein heterodimerization activity; retinoid X receptor binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription activator activity; transcription activator binding; transcription activator binding; transcription factor activity; transcription repressor activity; zinc ion binding