Recombinant Human POT1 Protein, His-tagged

• Cat.No.: POT1-2608H
• Product Overview: Recombinant Human POT1 Protein (Met1-Ala177) with a N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Met1-Ala177
• Description: This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 23.5 kDa
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: POT1 protection of telomeres 1 homolog (S. pombe) [ Homo sapiens (human) ]
• Official Symbol: POT1
• Synonyms: POT1; protection of telomeres 1 homolog (S. pombe); protection of telomeres protein 1; DKFZp586D211; hPot1; POT1-like telomere end-binding protein; HPOT1
• Gene ID: 25913
• mRNA Refseq: NM_001042594
• Protein Refseq: NP_001036059
• MIM: 606478
• UniProt ID: Q9NUX5