Recombinant Human POLR2A
Cat.No. : | POLR2A-30767TH |
Product Overview : | Recombinant fragment containing the carboxy-terminal repeat domain of Human RNA polymerase II with a proprietary 25kDa tag at N-terminus. |
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Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | 580 amino acids |
Description : | This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the RNA polymerase beta chain family. |
Gene Name | POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa [ Homo sapiens ] |
Official Symbol | POLR2A |
Synonyms | POLR2A; polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; POLR2, polymerase (RNA) II (DNA directed) polypeptide A (220kD); DNA-directed RNA polymerase II subunit RPB1; POLRA; RPB1; |
Gene ID | 5430 |
mRNA Refseq | NM_000937 |
Protein Refseq | NP_000928 |
Uniprot ID | P24928 |
Chromosome Location | 17p13.1 |
Pathway | Abortive elongation of HIV-1 transcript in the absence of Tat, organism-specific biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; |
Function | DNA binding; DNA-directed RNA polymerase activity; RNA-directed RNA polymerase activity; metal ion binding; nucleotidyltransferase activity; |
◆ Recombinant Proteins | ||
POLR2A-30767TH | Recombinant Human POLR2A | +Inquiry |
POLR2A-2513H | Active Recombinant Human POLR2A, CT Domain, His-tagged | +Inquiry |
POLR2A-6920M | Recombinant Mouse POLR2A Protein, His (Fc)-Avi-tagged | +Inquiry |
POLR2A-29986TH | Recombinant Human POLR2A, His-tagged | +Inquiry |
POLR2A-1149H | Active Recombinant Human POLR2A, CT Domain | +Inquiry |
◆ Cell & Tissue Lysates | ||
POLR2A-3037HCL | Recombinant Human POLR2A 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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