Recombinant Human POLL, His-tagged

• Cat.No.: POLL-28363TH
• Product Overview: Recombinant full length human DNA Polymerase lambda with a N terminal His tag. Mw: 36kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 320 amino acids
• Description: This gene encodes a DNA polymerase. DNA polymerases catalyze DNA-template-directed extension of the 3-end of a DNA strand. This particular polymerase, which is a member of the X family of DNA polymerases, likely plays a role in non-homologous end joining and other DNA repair processes. Alternatively spliced transcript variants have been described.
• Conjugation: HIS
• Molecular Weight: 36.000kDa
• Tissue specificity: Expressed in a number of tissues. Abundant in testis.
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.02% DTT, 0.32% Tris HCl, 0.58% Sodium chloride, 30% Glycerol
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH TKTAQMWYQQ GFRSLEDIRS QASLTTQQAI GLKHYSDFLE RMPREEATEI EQTVQKAAQA FNSGLLCVAC GSYRRGKATC GDVDVLITHP DGRSHRGIFS RLLDSLRQEG FLTDDLVSQE ENGQQQKYLG VCRLPGPGRR HRRLDIIVVP YSEFACALLY FTGSAHFNRS MRALAKTKGM MLMHHQKYLQ RFLGGKREKK QKEACSIPGI GKRMAEKIIE ILESGHLRKL DHISESVPVL ELFSNIWGAG SLSEHALSTA VVRNTHGCKV GPGRVLPTPT EKDVFRLLGL PYREPAERDW
• Sequence Similarities: Belongs to the DNA polymerase type-X family.Contains 1 BRCT domain.

Gene Information

• Gene Name: POLL polymerase (DNA directed), lambda [ Homo sapiens ]
• Official Symbol: POLL
• Synonyms: POLL; polymerase (DNA directed), lambda; DNA polymerase lambda
• Gene ID: 27343
• mRNA Refseq: NM_001174084
• Protein Refseq: NP_001167555
• MIM: 606343
• Uniprot ID: Q9UGP5
• Chromosome Location: 10q23
• Pathway: BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Non-homologous end-joining, organism-specific biosystem
• Function: DNA binding; DNA binding; DNA-directed DNA polymerase activity; DNA-directed DNA polymerase activity; catalytic activity