Active Recombinant Human PLG Protein

Cat.No. : PLG-67H
Product Overview : Recombinant Human PLG Protein extracellular domain 530-790aa (signal peptide removed), fused with no tag, was expressed in Pichia.
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Species : Human
Source : P.pastoris
Tag : Non
Protein Length : 530-790 a.a.
Description : Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. It can also cleave fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4.
Predicted N Terminal : Tyr 530
Form : Lyophilized from sterile PBS, pH 7.4.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : The recombinant mature microplasminogen consists of 261 amino acids and has a calculated molecular mass of 28.5 KD.
Endotoxin : <1.0EU/ug, LAL method
Purity : >95% (SDS-PAGE)
Stability : Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage : Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name PLG plasminogen [ Homo sapiens ]
Official Symbol PLG
Synonyms PLG; plasminogen; plasmin; DKFZp779M0222;
Gene ID 5340
mRNA Refseq NM_001168338
Protein Refseq NP_001161810
MIM 173350
UniProt ID P00747
Chromosome Location 6q26
Pathway Activation of Matrix Metalloproteinases, organism-specific biosystem; Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Degradation of the extracellular matrix, organism-specific biosystem;
Function apolipoprotein binding; cell surface binding; peptidase activity; protein binding; protein domain specific binding; serine-type endopeptidase activity;

Not For Human Consumption!

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